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I make it 150 to go with J-10o. The player in the big blind calls with Q-4o. He is a loose and aggressive player. The flop comes 4-8-10 and I lead out by making it 300 to go. He calls. The turn brings a ten giving me two pair

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I think you have trips here. Did you mean a jack on the flop? If you have two pair on the turn you should bet this to get hands like Q4 to fold or make a bad call.

Bet the turn.

Good luck,
PN