I think the obvious line HU is to call the flop and raise the turn (ideally on a scary card). I take this line frequently against somebody who will autoraise my blind on ace-rag but will fold without a pair, or somebody who will check-fold fourth street. Sometimes you need to bet the busted draw on the river. I like raising the hand on 4th street particularly because you will have a ton of outs in order to re-bet on the river if you hit.