[BluffTHIS!]

Well the key difference between holdem and plo is that the situations where there is 1st nut flush or full versus the 2nd nut occurs way more often. And the drawing hands run bigger and some big draws are actually favorites over sets. And even though shorthanded you don't expect nearly as often to run into these situations, they do occur and you just have to be prepared both to lay down the 2nd nuts and also not to try to push bluffs too far against determined calling stations. And as far as where to play, you can often just sit at a table if you want headsup or 3 way action. But until you do adjust and learn more it would be prudent to do so at lower limits although more of the players willing to play shorthanded plo play high.

Besides the posts here, there is a ton in the archives, and you should also read the basic plo texts often mentioned here, namely Ciaffone and Ciaffone/Reuben.