Do you have the bankroll to leapfrog from 1-2 to 3-6?

Since your 1-2 sample size is small, the short term runs of LAGs and calling stations still strikes you as remarkable (though I too can be incredulous at times) and there are good 2-4 options, might make sense to go that route.

I am limited to pokerroom at the moment (mac user) and agree that there are very juicy 2-4 games, though table selection can be pretty small and it is 5 max vs. 6 max.