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fold preflop, and yes, call the river. you have a straight, and he has trip sixes more than often enough to call.

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fold preflop? i'm opening from the button...

I thought shorthanded it was fairly standard to raise A LOT when opening from the button

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check this out on stealing. It's geared at STT audiences, but I think it's applicable to SH play. Figure the guy for the /loose/ category, then determine your equity. I think it's slim with this hand.