[jrz1972]

[ QUOTE ]
Say I'm against 2 loose opponents, I have AKo from the CO and raise, 2 of the 3 remaining are probably going to call, then a ragged flop hits, I bet I will be called at least by 1 of them almost every time. So I'm unsure of my action from this point on. When I check the turn they will bet at me 80% of the time on the river. and when i bet the turn they'll show down with 82o and win.

[/ QUOTE ]

A decent rule of thumb in these situations (HU in position with AK) is to bet the turn against a loose-passive with the intention of taking a "free" showdown on the river. You're often ahead so a bet protects your hand and carries some value against players who will call with a weaker A or a weak draw.

Against an aggressive player, a better strategy will often be to check behind on the turn with the intention of calling a river bet. Give LAGs a chance to bluff at the pot.

Obviously the board and opponent-specific reads can be used to refine these lines.