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I think the closest parallel will be the early game of Indy @ San Fran. Edge ended with 105 and a touch, and the only reason you didn't see more out of that game was that Peyton tossed three touchdowns: Indy was up two touches at halftime, three touchdowns in the third quarter, and a four touchdown lead. I think Seattle's offense is obviously more potent than Indy's this year, and has a solid defense to match to the terrible San Fran offense.

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I disagree with most of this. Note also that Alex Smith threw 4 picks, one of which was returned for a TD, and lost a fumble in the Indy 28-3 game.