In this situation, 5 handed in the 22s, I would have to assume I am up against a pair or an Ace-Something (AA, KK, QQ, JJ, TT, 99, 88, 77, 66, 55, 44, 33, 22, AK, AQ, AJ, AT, A9, A8, A7, A5, A4, or A3) and fold the A6 with no hesitation. Have a nice day!