Depends. Heads-up, I'll bet (hoping the PFR will raise like he should) and call. I'll check the turn, he'll bet thinking I'll fold, and I'll check-raise there. I'll use this about 50-75% of the time in that situation.

With a few people in the pot, it depends on the texture of the flop. If it's non-threatening, I'll check hoping to trap a few callers, and then raise (or re-raise even).