[kiddj]

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This may sound a bit shortsighted, but how can you misapply information if you don't have any to begin with?

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If an opponent bets into you, and you have no info on him, you make your decision based on the cards, odds, or whatever. This doesn't sound too terrible, right?

But, if you have a read on him that he NEVER bluffs, but you call/raise him anyway (with nothing), is this not MUCH worse?

At best, the 2 can only be equal. If you draw incorrectly without knowing the odds, you're making an equal mistake to the person who knows the odds and draws anyway.