[mmcd]

Is this game profitable?

Of course not, and anyone that tells you otherwise is lying.

How can you expect to have an edge in a game when 4 or 5 drunk guys are auto-capping the first two betting rounds?

If you wait for big hands, you'll find yourself blinded away, then when you finally get a monster, it will almost certainly get cracked, so you have to get in there and mix it up with them. It would be like playing roulette, you put your money down and just hope you win at the end of the hand, but since there are 5 of them and only one of you, they will win most of time.