The plus side that no one has touched on (or my reading skills are shot) is that there's going to be little rake at a super-tight/passive .50-1 table. If you keep winning $2 pots, you never have to give up a cut to the house.

And a slow grind with small pots also means less variance.

The only problem I see is that maybe you're risk-averse, which is why you don't just play 6-max, where it's much looser. So, you might be uncomfortable with the more aggressive play you need to win at the tight tables. That would be a problem.