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Mandalay Bay is ALL the way at the south end of the strip - that makes it fairly inconvenient to get to other casinos.
The Bellagio is a MUCH better location - as is the Wynn.
The nice thing about the Wynn for your wife is that it is right across from the mall.
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Also, don't let this map deceive you as to how far apart things are.
i.e. I thought the walk from Excalibur to Rio would be cake. whoops.
(I think it took about an hour)