Trust me on either of these two these two...
Brigtsen's It's uptown, and the streetcer takes you within 2 blocks.
Gabrielle Up Esplanade in Mid city, take a taxi.
Both of these chefs trained under Paul Prudhomme and are the best contemporary creole restaurants in the city. Easily better than K-Paul's.
Also, and I say this to everyone, an afternoon at Napoleon house, drinking old fashioned drinks that you'd ordinarily never order, is mandatory.
The Grill Room in the CBD has a $75 dollar tasting menu (maybe another $60 or so with paired wines) that is top notch indeed.