[SheetWise]

It would depend a lot on how long/often they played, and what the house expectation was on the game.
For example, consider two players who each place opposing $100 wagers outside on a roulette wheel -- and that is their only bet. 18 out of 19 times one player will end up with $200 and the other player with $0. 1 out of 19 times the house will win $200 giving them an expectation of $10.53 for the single trial.

Given your example -

One Player loses $100
One Player wins $89.47
House wins $10.53

Then -

House pays loser $25
House pays winner $8.95
House Net = (23.72)