[NYCNative]

I asked this question in the small stakes NL section because at that level it is less likely villain is capable of making big laydowns. The overwhelming response was that if you have the kind of David hand that can slay a Goliath (i.e. a suited connector or a smaller PP which will result in getting paid off if you flop a set) that it is smart to make such plays with the caveat that you have to play well post-flop and you have to be disciplined enough to get rid of it when the flop teases instead of pleases. (Not that you have to flop your full house to make it worth it, but you have to know whether the price villain charges for you to see a turn and/or river makes sense.)

It also helps if villain sucks (i.e. he will slowplay monsters, check a flop hoping to CR when you're smart enough to take the frere card, etc.) but doesn't it always?