[La Brujita]

Also depends a little where your office will be. I personally like either Union Square area or 11th-14th streets around 6th-8th aves. Latter has very nice places, beautiful streets, quiet but in the center of the action.

Edit to say after reading other responses living around W 4th street (which I did for a summer) is another idea. The reason I didn't put it on is it is a little louder and dirtier and is a very easy walk from a little north.