[playersare]

for speculative, multiway hands like strong suited neighbors and middle pocket pairs, you need to have at least several existing cold callers, or be absolutely certain that there will be weak callers behind you in order to justify the odds of hitting. like other posters said, the situations where this would occur would be extremely rare, and even if it came up, it would never be completely "wrong" to chuck it anyway.

if you do have a legitimate Group 1 holding (or possible Group 2 if the raiser is loose), especially a "one-way" hand like AKo, the only choice is to reraise and isolate the player to your right, buy yourself late position heads-up. you need to have the higher EV cards preflop at least 50% of the time against the raiser going in, for this play to be profitable in the long run.