[shmahappens]

This situation usually happens to me when I've been isolating a complete idiot with much weaker hands than AQs and AK, I think a player who is good enough to be confident he can beat you postflop (by sacrificing some PF equity) won't continue this if you're only isolating with AQs or better (as it will be much tougher to push your off your hand, so he has to hit to win and is sacrificing a lot more PF equity).
Assuming he is calling with most any two just on the basis of position and his better play, your hand doesn't have to 'hit to win' as much as I think you implied in your post. Try looking for situations that from his perspective would be a good time to steal from you (ie: raising scare cards, midling flops).
And yes, these situations annoy me too.
If he persists then tighten up your isolating hands, as with the less powerful hands you'll have a smaller edge against him, which he will be able to overcome with better postflop play.