"Longhanded" Hold 'Em Strategy?

[Phat Mack]

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Assuming you could solve the logistical issues -- e.g., finding a large enough table -- does anybody have any thoughts on strategy adjustments for playing limit and NL hold 'em with 15-22 players?

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Interesting question. There are too many variables (format, stakes, players seeing the flop, players chasing, pot & implied odds) to give any worthwhile answer. While all hand values would depreciate, what changes the most in these games would be the value of marginal hands, so hands like TPTK and 2 pair could become traps at showdown.