The wee hours of the morning aren't that great in my experience. Most people still up are trying to get even and play somewhat tighter. Also, tables are dissolving and consolidating as people leave. Lots of tables are shorthanded which makes it very difficult to overcome the rake at low limits (3/6 & 4/8).

The best time to play is Friday evenings/nights from 6pm - 1am, Saturday afternoon/evening, and Sunday afternoons - my personal favorite as lots of people are paying more attention to football than the poker game (at least this time of year) and drinking like the fish they are.