[Warren Whitmore]

Yes it does matter.
If you are a much better that average player you should chose a handle like AAron. If you are a below average player you should chose a name like 8J2biz.

This is because good players track opponants. If you practice game selection well and find a comfortable table it will remain comfortable longer if other strong players recognize your handle as one to avoid. This will change the ratio of people entering the game towards the weaker (none tracking players).