I ran some numbers at two dimes and there are actually cases where you have odds to call, depending on how big of an idiot the two callers are:
<font class="small">Code:</font><hr /><pre>
5-card Draw 2-7 Lowball: 15600 enumerated outcomes
cards win %win lose %lose tie %tie EV
8s 6c 4d 3d 3556 22.79 11884 76.18 160 1.03 0.233
6s 4s 9d 7d 2d 6264 40.15 9336 59.85 0 0.00 0.402
6d 7h 4h 3h 1748 11.21 13784 88.36 68 0.44 0.114
4c 2c 8h 6h 3872 24.82 11636 74.59 92 0.59 0.251
</pre><hr />
but most likely you are a big dog:
<font class="small">Code:</font><hr /><pre>
5-card Draw 2-7 Lowball: 15600 enumerated outcomes
cards win %win lose %lose tie %tie EV
8s 6c 4d 3d 1659 10.63 13941 89.37 0 0.00 0.106
6s 4s 8d 7d 2d 8096 51.90 7080 45.38 424 2.72 0.533
6d 7h 4h 2h 3600 23.08 11576 74.21 424 2.72 0.244
5c 2c 8h 6h 1821 11.67 13779 88.33 0 0.00 0.117
5-card Draw 2-7 Lowball: 15600 enumerated outcomes
cards win %win lose %lose tie %tie EV
8s 6c 4d 3d 1950 12.50 13650 87.50 0 0.00 0.125
6s 5s 9d 7d 2d 6303 40.40 9297 59.60 0 0.00 0.404
6d 7h 4h 2h 4532 29.05 11068 70.95 0 0.00 0.291
5c 4c 2c 8h 2815 18.04 12785 81.96 0 0.00 0.180
</pre><hr />
even more so if one of the cards you need has been discarded (a 2 and a 5, respectively
<font class="small">Code:</font><hr /><pre>
5-card Draw 2-7 Lowball: 15600 enumerated outcomes
cards win %win lose %lose tie %tie EV
8s 6c 4d 3d 1659 10.63 13941 89.37 0 0.00 0.106
6s 4s 8d 7d 2d 8096 51.90 7080 45.38 424 2.72 0.533
6d 7h 4h 2h 3600 23.08 11576 74.21 424 2.72 0.244
5c 2c 8h 6h 1821 11.67 13779 88.33 0 0.00 0.117
5-card Draw 2-7 Lowball: 15600 enumerated outcomes
cards win %win lose %lose tie %tie EV
8s 6c 4d 3d 1322 8.47 14278 91.53 0 0.00 0.085
6s 4s 8d 7d 2d 8921 57.19 6235 39.97 444 2.85 0.586
6d 7h 4h 2h 3000 19.23 12156 77.92 444 2.85 0.207
5c 2c 8h 6h 1913 12.26 13687 87.74 0 0.00 0.123
</pre><hr />