Biggest Movie Upset?

[offTopic]

For whatever reason, I don't mind if an anonymous nobody kills a big star, especially if it's central to the story (the bartender back-shoots John Wayne in The Shootist, or the released German soldier shoots Tom Hanks in Saving Private Ryan, for instance) or, if its a group effort (Bolivian Army kills Butch & Sundance) but it always bugs me when a "that guy" (as Bill Simmons would label him) gets over on one of the biggies.

What was the biggest movie upset - where an obscure actor kills an A-lister?

Personal picks:

- John Leguizamo kills Al Pacino in Carlito's Way
- Billy Drago kills Sean Connery in The Untouchables
- Marlon Wayans kills Tupac in Above The Rim